Haitham Amal, Ph.D. - Principal Investigator
The Amal lab combines advanced omics technologies with computational biology, biochemical, pharmacological and behavioral methods. This allows us to unravel novel molecular mechanisms in the brain under physiological and pathological conditions. The Laboratory of Neuromics, Cell Signaling, and Translational Medicine is interested in understanding how signaling pathways are integrated at the molecular, cellular, and systems levels to control cellular functions. The Amal Lab uses proteomics to measure protein expression level and to characterize their post-translational modifications (PTMs). This gives us critical information on the cellular state. Further, we combine these multidisciplinary tools to discover novel drug targets and biomarkers in autism spectrum disorder (ASD), Alzheimer's disease (AD), and other pathologies. The Lab uses both clinical material and transgenic mouse models to achieve our ultimate goals. Our findings on mouse models will lead to translating the results of biomedical research from preclinical to clinical stages.